A dose 210 mg of carnosine only lasts about 5 hours in the blood before begin degraded by
carnosinase enzymes.
These authors have hypothesized that CNP is a non-secreted enzyme and differs from those secreted such as serum
carnosinase and anserinase, with a limited expression, and that arise by the effect of the second duplication of the gene once the urochordates separated from the vertebrate to evolve as secreted enzymes.
Porem, a suplementacao de carnosina oral e um metodo ineficiente para elevar os niveis de carnosina muscular nos seres humanos (Gardner e colaboradores, 1991) devido ao fato de nao ser absorvida em sua forma integra, ja que no aparelho digestorio esta presente a enzima
carnosinase que rapidamente hidrolisa este dipeptideo, como mostra a Figura 1 (Sale, Saunders e Harris, 2010; Hobson e colaboradores, 2012).
The localization of the gene on chromosome 18q22.3-23 was the first identified genetic loci in Turkish DKD patients of T2DM [4], which is in the region of
carnosinase genes, and the polymorphism of relevant genes of carnosine dipeptidase (CNDP)1 and 2 was later proved to be related with the progression of DKD in T2DM patients [5,6].
Due to individual differences in plasma
carnosinase levels, there is significant variability in response to carnosine ingestion.
A administracao direta de carnosina nao aumenta os seus estoques musculares, pois ela e rapidamente hidrolisada pela enzima
carnosinase, presente no plasma humano (Asatoor e colaboradores, 1970; Perry e colaboradores, 1967).
Guarino et al., "
Carnosinase levels in aging brain: redox state induction and cellular stress response," Antioxidants and Redox Signaling, vol.
A new test, which compares he levels of the chemicals enolase (which brain cells release when they die) and
carnosinase (production halts because of brain cell death) in the blood, may help families of stroke victims prepare for the future.
That's because the amount of carnosine in meat is rapidly degraded by
carnosinase enzymes in your body.
initially postulated that the CNDP1 gene on chromosome 18q22.3-q23, encoding serum
carnosinase (CN-1), is a susceptibility gene for dN in type 2 diabetes mellitus (T2DM) patients [10].