carbonic anhydrase inhibitors

A class of drug that act by blocking the action of the enzyme CARBONIC ANHYDRASE. This enzyme greatly speeds up the reaction between carbon dioxide and water to form carbonic acid, a compound needed for the production of many of the body's secretions. Carbonic anhydrase is present in high concentration in the eye, the kidneys, stomach lining and pancreas. Inhibitor drugs reduce the rate of secretion of aqueous humour in the eye and is useful in treating GLAUCOMA. These drugs are also valuable in treating mountain sickness, periodic paralysis and absence attacks (petit mal). The group includes ACETAZOLAMIDE and DORZOLAMIDE.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

carbonic anhydrase inhibitors

Drugs which inhibit the carbonic anhydrase enzyme in the ciliary epithelium of the ciliary body. This enzyme is essential for the formation of aqueous humour; its reduction results in a decrease in intraocular pressure. Those in use are sulfonamide derivatives. They are administered systemically (e.g. acetazolamide) or topically in the treatment of glaucoma. Examples: acetazolamide, brinzolamide, dichlorphenamide, dorzolamide.

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References in periodicals archive

c) Alpha adrenergic agonists and carbonic anhydrase inhibitors may not be effective at reducing IOP sufficiently

Glaucoma medication

These results are consistent with the results obtained through the study carried out by Pichake et al., 2014, [58] in order to evaluate human carbonic anhydrase inhibitors. In this study importance of nature of substitution on para position was discussed.

Tyrosinase and Carbonic Anhydrase Enzymes Inhibition Studies of Vanadium(V) Complexes

Osmotic diuretics (like mannitol) and carbonic anhydrase inhibitors (like acetazolamide) produce an opposite effect comparing to the majority of the other diuretics, decreasing lithium concentration (being therefore classically used to treat lithium's intoxication).

Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics--A review

Supuran, "Glaucoma and the applications of carbonic anhydrase inhibitors," in Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications, vol.

Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors

Decreased macular thickness in nonproliferative macular telangiectasia type 2 with oral carbonic anhydrase inhibitors. Retina.

Efficacy of intravitreal bevacizumab in treatment of proliferative type 2 idiopathic juxtafoveal telangiectasia

Browse Glaucoma Therapeutics Market by Drug Class (Alpha Agonist, Beta Blockers, Carbonic Anhydrase Inhibitor, Cholinergic, Combined Medication, Prostaglandin Analogs), End Users (Ambulatory Surgical Centers, Hospitals, Ophthalmic Clinics) and Forecast 2017-2021 at https://www.ihealthcareanalyst.com/report/glaucoma-therapeutics-market/

Glaucoma Therapeutics Market Analysis and Forecast 2017-2021, Upcoming Report by iHealthcareAnalyst, Inc.

The different groups of drugs prescribed were P-blockers (41.66%), prostaglandin analogs (33.33%), [[alpha].sub.2] adrenergic receptor agonist (16.66%), and carbonic anhydrase inhibitors (08.33%) Figure 1.

Prescribing pattern and adverse events of drugs used in patients with primary open-angle glaucoma (POAG) attending a tertiary care hospital: Retrospective study

One is to promote uveoscleral outflow, such as prostaglandin (PG) analogs, [alpha][beta]-adrenergic receptor blockers, a1-adrenergic receptor blockers, and a2-adrenergic receptor agonists, and the other is to suppress aqueous humor production, such as [beta]-adrenergic receptor blockers, carbonic anhydrase inhibitors (CAI), and [alpha][beta]-adrenergic receptor blockers [23].

Additive Intraocular Pressure-Lowering Effects of Ripasudil with Glaucoma Therapeutic Agents in Rabbits and Monkeys

Supuran, "Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions," Bioorganic and Medicinal Chemistry Letters, vol.

Inhibition of Horseradish Peroxidase Activity by Boroxine Derivative, Dipotassium-trioxohydroxytetrafluorotriborate [K.sub.2][[B.sub.3][O.sub.3][F.sub.4]OH]

Case 4###72###Male###Right###Beta blocker, , alpha agonist, Carbonic anhydrase inhibitors, Prostaglandin analouge

Pain management with retrobulbar alcohol injection in absolute glaucoma

Carbonic anhydrase inhibitors and ventilation: a complex interplay of stimulation and suppression.

The role of anion exchanger on pulmonary vascular response to sustained alveolar hypoxia in the isolated perfused rabbit lung

Control of intracranial pressure is done with medical therapy like carbonic anhydrase inhibitors, antiplatelets and high dose steroids.

Bilateral papilloedema in a case of reactivated breast carcinoma secondary to idiopathic intracranial hypertension