cancer susceptibility

An inherent proneness toward suffering from cancer.

Fringe oncology
Advocates of unproven methods of cancer care may evoke psychoneuroimmunology arguments that certain personality types or individuals with specific mental health profiles are at an increased risk of acquiring cancer.

Cancer Susceptibility—fringe oncology arguments
• Maternal domination;
• Immature sexual adjustment;
• Inability to express emotions and hostility;
• Inability to accept significant losses;
• Pre-neoplastic feelings of despair, hopelessness and self-pity;
• Poor self-image and interpersonal relationships;
• Lack of closeness to parents.

Mainstream oncology
A tangible risk of suffering cancer, based on chromosome and DNA analysis.

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References in periodicals archive

Presently, many genetic testing panels for cancer susceptibility are available in the market.

Genetic Testing Panels Market to Increase at Steady Growth Rate

The laboratory seeks a broad understanding of factors related to cancer susceptibility using knowledge derived from epidemiologic studies as well as fundamental cellular and molecular biology.

GeneCentric and Collaborators at Washington University Advance Academic-Industry Head and Neck Cancer Partnership under NCI Grant

The EC has approved the product as monotherapy treatment for adult patients with germline breast cancer susceptibility gene (gBRCA)1/2-mutations, who have human epidermal growth factor receptor 2-negative (HER2-) locally advanced or metastatic breast cancer.

European Commission approves Pfizer's Talzenna

BioMarin Pharmaceutical (BMRN) announced that the company earned a $15M milestone payment from Pfizer (PFE), triggered by the European Commission approval of Talzenna as monotherapy for the treatment of adult patients with germline breast cancer susceptibility gene 1/2-mutations, who have human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer.

BioMarin says EC approval of Talzenna triggers $15M milestone payment

Certain inherited PTEN mutations can cause syndromes characterized by cancer susceptibility and developmental defects.

Broccoli Compound Reawakens Tumor Suppressor

Number of studies highlighted the role of XPD polymorphisms in cancer susceptibility including, lung, [5] prostate, [12] breast, [8] and head and neck cancer [3,4] among different ethnic populations, whereas other studies failed to find positive association of XPD polymorphism in the head and neck cancer [22] or breast carcinoma.

Association of polymorphisms of xeroderma pigmentosum complementation group D gene with cervical cancer in Maharashtrian population: A case-control study

This is the first novel mutation ever reported in a Moroccan family associated with colon cancer susceptibility. Identification of such mutations is crucial and can widely aid in the management of colorectal cancer in predisposed populations through molecular screening, prevention strategies, and follow-up of suspected LS families.

Molecular and presymptomatic analysis of a Moroccan Lynch syndrome family revealed a novel frameshift MLH1 germline mutation

On further questioning, the patient reports she had triple-negative (estrogen receptor-, progesterone receptor-, and human epidermal growth factor receptor 2 [HER2]-negative) breast cancer, a feature of patients with germline BRCA1 (breast cancer susceptibility gene 1) mutations.

Who needs breast cancer genetics testing? Identifying patients who are appropriate candidates for breast cancer genetics testing is a key step toward prevention and value-based care

'This research also provides a foundation for others to investigate the DNA loci and associated genes that play roles in skin cancer susceptibility and the effects of UV radiation."

Human Genome Linked to Skin Color Variation

Multiple large studies of the matched normal germ line variants in cancer patients have revealed that mutations in cancer susceptibility genes are significantly more common than previously thought (3)?

Clinical and Genomic Insights from Metastatic Cancers