Medical

brefeldin A

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brefeldin A

A macrocyclic lactone synthesised from palmitic acid by several fungi, which has antiviral activity.

Immunology
Brefeldin A inhibits exocytosis and antigen processing for MHC-I-restricted T cell recognition.

Membrane biology
Brefeldin A blocks the movement of proteins from the endoplasmic reticulum to the Golgi system. It is used to study protein kinetics.

References in periodicals archive

One of these promising anticancer drugs is Brefeldin A (BFA), a cyclic macrolide with a lactone ring.

The main goal of this research programme is to couple Brefeldin A (BFA) with Aphios' SuperFluids critical fluid nanosomes (SFS-CFN) technology for intravenous administration to achieve and maintain therapeutic plasma concentrations.

Subcontract for nanoformulation of super hydrophobic anticancer drug granted to Aphios

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