Brazilin (1), Brazilein (2) and Sappanone B (3) from the Chinese drug Sappan Lignum, the heartwood of Caesalpinia sappan L.
The three 3-Benzylchroman derivatives Brazilin (1), Brazilein (2) and Sappanone B (3) were isolated from Sappan Lignum, the heartwood of C.
The data were in agreement with those of Brazilein (Kim et al.
Compounds 1-3 alone showed moderate to weak activity against MSSA by MICs/MBCs ranged 32-128/64-512 ptg/ml, with the order of activity as Brazilin (1)> Brazilein (2) > Sappanone B (3) (Table 1).