beta-gamma bridge
beta-gamma bridge
An elongating of the usually well-defined peaks in the beta and gamma regions in a Serum protein electrophoresis (SPEs), which occurs in chronic liver disease, classically in alcoholic liver disease, as well as in chronic infections and connective-tissue disease; it is due to polyclonal production of proteins that migrate in the region, which may “bury” small monoclonal expansions, or the clone may produce polymeric forms of a protein, resulting in differences in electrophoretic mobility, causing a “pseudo-polyclonal” expansion.
Beta-migrating proteins
Transferrin and beta-lipoprotein.
Gamma-migrating proteins
IgG, IgA, IgM.Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
beta-gamma bridge
Immunology A 'spanning' of the usually well-defined peaks in the β and γ regions in an SPEP which occurs in chronic liver disease, classically in alcoholic liver disease, as well as in chronic infections and connective tissue disease, and is due to polyclonal production of proteins that migrate in the region, which may 'bury' small monoclonal expansions. See serum protein electrophoresis. McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive
Table 2 and Figure 2 illustrate the electrophoretic pattern of serum hypoalbuminemia, hypergammaglobulinemia, and a
beta-gamma bridge. The beta-gamma bridging was caused by fast moving gamma globulins, preventing distinct bands from appearing between the gamma and beta globulin fractions, and therefore forming a bridge between the two.
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