Tau phosphorylation affects its
axonal transport and degradation.
Because HDAC6 is involved in cytoskeletal formation, modulation of cellular oxidation/reduction state, and the ubiquitin-proteasome system, inhibition of HDAC6 improves pathological conditions in neurons such as impairments in
axonal transport, oxidative stress, and protein aggresome formation in vitro [18, 19].
Mechanisms of the inhibition of fast
axonal transport by local anesthetics.
Therefore, it stands to reason that the integrity of the microtubule transport system is crucial for
axonal transport [129].
Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and
axonal transport. Hum.
Small quantities of botulinum toxin can undergo retrograde
axonal transport to the central nervous system, but there is no evidence that this has any effect on humans.
* Retrograde
axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult.
Subcellular structure,
axonal transport mechanisms and the structural basis of electrical and chemical signalling are described concisely.
showed that
axonal transport and presynaptic release of TDP-43 could potentially be a route of transmitting TDP-43 to the postsynaptic cells [80].
The transport of the administered drug into extradural or subarachnoid space either by diffusion or by the centripetal
axonal transport results in central action.