autonomic failure

A condition characterised by sympathetic and often parasympathetic failure. AF can be divided into primary, secondary and drug-induced forms, with considerable overlap.

Aetiology
AF may be evoked by or associated with ageing, alcohol consumption, carcinomatous autonomic neuropathy, CNS disease, dopamine beta-hydroxylase deficiency, familial dysautonomia (Riley-Day syndrome), idiopathic orthostatic hypotension, Parkinson’s disease, and Shy-Drager syndrome.

Clinical findings
Syncope, orthostatic hypotension.

autonomic failure

Neurology A condition characterized by sympathetic and often parasympathetic failure; Clinical Syncope, orthostatic hypotension; AF can be divided into 1º, 2º, and drug-induced forms with considerable overlap Etiology AF may be evoked by or associated with aging, alcohol imbibition, carcinomatous autonomic neuropathy, CNS disease, dopamine β-hydroxylase deficiency, familial dysautonomia or Riley-Day syndrome, idiopathic orthostatic hypotension, Parkinson's disease, Shy-Drager syndrome. See Baroreflex failure.

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References in periodicals archive

Autonomic failure is an integral component of Parkinson's disease (PD), and orthostatic hypotension (OH) can be an important clue to the underlying cardiovascular autonomic failure.

Autonomic cardiovascular regulation in Parkinson's disease by head-up tilt test - A cross-sectional study

According to a new LSU Pennington Biomedical Research Center USA study, a novel biomarker might give us answers necessary to create a diagnostic tool for hypoglycemia-associated autonomic failure (HAAF).

Study provides clue to prevent low blood sugar in diabetics

According to a new LSU Pennington Biomedical Research Center study, a novel biomarker might give us answers necessary to create a diagnostic tool for hypoglycemia-associated autonomic failure (HAAF).

Study provides clue to prevent low blood sugar in diabetics

Neurogenic OH (NOH), a commonly overlooked subtype of OH, is associated with nervous system impairment, and is predominantly seen in neurodegenerative disorders such as PD, multiple system atrophy (MSA), and pure autonomic failure (PAF).

Recognition and Management of Orthostatic Hypotension in Primary Care

A systematic review of autonomic dysfunction in [alpha]-synucleinopathies revealed that cardiovascular autonomic failure has a significant impact on daily activities and QoL.

Quality of Life in Patients with Dementia with Lewy Bodies

The Ewing score (ES) ranging from 0 (normal) to 5 (severe autonomic failure) represents the sum of the responses to the different tests.

Predictors of Cardiovascular Autonomic Neuropathy Onset and Progression in a Cohort of Type 1 Diabetic Patients

Practical bedside investigation of diabetic autonomic failure. In: Autonomic failure.

Evaluation of autonomic status during three trimesters of pregnancy

Other important examinations that can be done in order to understand the complex differential diagnosis of this syndrome include total sweating test to recognize areas of anhidrosis, cardiovascular reflex tests to recognize the presence of autonomic failure, microneurography from the peroneal nerve to record muscle sympathetic nerve activity and skin sympathetic nerve activity in the same innervation field, and a skin biopsy.

Idiopathic Harlequin Syndrome Manifesting during Exercise: A Case Report and Review of the Literature

who found length-dependent somatic and autonomic small fiber damage, both in patients with PD and in those with pure autonomic failure (PAF).

Should Skin Biopsies Be Performed in Patients Suspected of Having Parkinson's Disease?

Probable MSA also specifies that the patient show either autonomic failure involving urinary incontinence--this includes erectile dysfunction in men--or, if autonomic failure is absent, orthostatic hypotension within 3 minutes of standing by at least 30 mm Hg systolic pressure or 15 mm Hg diastolic pressure.

Depressed and confused, and dizzy while walking the dog