Deregulation of
Aurora kinase gene expression in human testicular germ cell tumours.
Also In May, the drug giant made another acquisition to strengthen its cancer franchise by announcing an agreement to acquire AurKa Pharma, a company established by TVM Capital Life Science to develop oncology compound AK-01, an
Aurora kinase A inhibitor that was originally discovered at Lilly.
AurKa Pharma was established as part of the TVM Life Science Ventures VII fund, to develop an
Aurora kinase A inhibitor called AK-01, an oncology compound that was originally discovered through a Lilly research and development program.
AurKa Pharma is a company established by investment advisory and fund managers group TVM Capital Life Science to develop oncology compound AK-01, an
Aurora kinase A inhibitor that was originally discovered at Lilly.
In a recent study of 25 prostatic adenocarcinomas with Paneth cell-like neuroendocrine differentiation, 45% showed amplification of the
Aurora Kinase A (AURKA) gene, which was associated with a higher percentage of Paneth cell-like neuroendocrine differentiation throughout the tumor, ductal features and a higher Gleason score.
The
Aurora kinase inhibitors in cancer research and therapy.
It is known that
Aurora kinase A and JAK2 pathway activation contributes to GVHD.
identified varying frequencies of aurora-A and aurora-B expression in myeloma samples using Affymetrix DNA microarrays and presence of aurora-A expression was associated with inferior event-free and OS [38]; however,
aurora kinase inhibitors have not been commercially available to translate this finding into clinical practice.
Live-cell imaging of a Forster resonance energy transfer (FRET)-based
aurora kinase phosphorylation sensor revealed that midzone substrates were less phosphorylated in AAK-inhibited cells, despite the fact that midzone levels of active phosphorylated ABK (pABK) were normal.
While reverse transcriptase PCR analysis of aurora kinase1 gene showed an aberrant amplification at passage 1 and 2, immunocytochemical analysis revealed overexpression of
aurora kinase B protein at passage 2 in the treated cells indicative of mitotic slippage by override of the checkpoint arrest through rapid exit from mitosis and defective spindle assembly checkpoint and aneuploidy resulting in genomic instability [35,46].
These include the three members of the
Aurora kinase family.