Concomitant RA medications were permitted at the discretion of the investigator and included: methotrexate, leflunomide, sulfasalazine, antimalarials,
auranofin injectable gold preparations, nonsteroidal anti-inflammatory drugs, and/or glucocorticoids at approved doses.[28]
Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis.
(168) Nora Yang,
Auranofin for Chronic Lymphocytic Leukemia,
Klegeris, "A new look at
auranofin, dextromethorphan and rosiglitazone for reduction of glia-mediated inflammation in neurodegenerative diseases," Neural Regeneration Research, vol.
crassiceps TGR was obtained by incubating an enzyme aliquot in the presence of a 4:1 molar excess of the irreversible inhibitor
auranofin [14].
A number of new molecules have been identified as inhibitors of IL-1[beta] processing (glyburide, parthenolide, CRID3,
auranofin, isoliquiritigenin, [beta]-hydroxybutyrate, and MCC950); however, confirming their clinical utility will require additional time and research [24].
cDMARDs n (%) Patients with at 11,511 (91.9%) least one treatment Methotrexate 9,508 (75.9%) Hydroxychloro quine 3,527 (28.2%) Leflunomide 3,275 (26.1%) Sulfasalazine 2,340 (18.7%) Sodium aurothiomalate 114 (0.9%) Azathioprine 98 (0.8%) Cyclosporine 89 (0.7%)
Auranofin 43 (0.3%) Penicillamine 28 (0.2%) Cyclophosphamide 10 (0.1%) bDMARDs n (%) Patients with at 3,697 (29.5%) least one treatment Etanercept 1,545 (12.3%) Adalimumab 1,329 (10.6%) Tocilizumab 618 (4.9%) Abatacept 481 (3.8%) Golimumab 376 (3.0%) Rituximab 339 (2.7%) Certolizumab pegol 273 (2.2%) Infliximab 68 (0.5%) Anakinra 3 (<1.0%) Table 3: Change in DAS28-ESR scores over a 6-month period.
Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3.
Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53.