"Our results hold the potential to markedly improve statin allocation in elderly individuals by de-escalating or even withholding preventive therapy in elderly individuals at truly low
atherosclerotic cardiovascular disease risk despite advancing age," wrote Martin Bodtker Mortensen, MD, PhD, of Aarhus (Denmark) University Hospital.
In their studies, the researchers compared SR-B1 and DOCK4 abundance in areas of the mouse aorta that are prone to plaque formation compared with regions less likely to become
atherosclerotic.
Notably, Most SCD patients (72.0%) had
atherosclerotic CAD (Fig.1).
The companies said the European Medicines Agency's CHMP has recommended a new indication for Praluent (alirocumab) Injection to reduce cardiovascular risk by lowering low-density lipoprotein cholesterol (LDL-C) levels as an adjunct to correction of risk factors in adults with established
atherosclerotic cardiovascular disease.
The researchers found that among participants without diabetes, the hazard ratios for statin use in 75- to 84-year-olds were 0.94 (95 percent confidence interval [CI], 0.86 to 1.04) and 0.98 (95 percent CI, 0.91 to 1.05) for
atherosclerotic CVD and all-cause mortality, respectively; for those aged 85 years and older, the corresponding hazard ratios were 0.93 (95 percent CI, 0.82 to 1.06) and 0.97 (95 percent CI, 0.90 to 1.05).
The CT scan revealed severe
atherosclerotic stenosis of the ostium of his right renal artery (Figure-1).
Several luminal angiography techniques, such as digital subtraction angiography, computed tomography angiography and magnetic resonance angiography, have been employed to evaluate intracranial
atherosclerotic stenosis, but these methods fail to delineate the vessel wall morphology properties and plaque components (4).
Blood lipid profile and size of coronary artery lumen and
atherosclerotic plaque were compared between the two groups.
Cheng et al., "Overexpression of cholesteryl ester transfer protein increases macrophage-derived foam cell accumulation in
atherosclerotic lesions of transgenic rabbits," Mediators of Inflammation, vol.
Low wall shear stress can cause arterial damage, and subsequently plaque instability, through several mechanisms, including increased fluid residence time and increased platelet and macrophage adhesion to the arterial wall.[sup][1] A highly sensitive and specific blood biomarker or protein profile could provide information on the stability and vulnerability of carotid
atherosclerotic plaques though such a discovery has yet to be made.