Antithyroid drug treatment for graves' disease in children: a long-term retrospective study at a single institution.
The American Thyroid Association (ATA)/American Association of Clinical Endocrinologists (AACE) 2011 and The ATA 2016 guidelines recommended methimazole (MMI) for the first line
antithyroid drug in the treatment of Graves' hyperthyroidism in nonpregnant patients [1, 2].
Keywords: Antenatal,
Antithyroid drug, Hyperthyroidism, Hypothyroidism, Thyroid cancer, Thyroid nodules, Lactation.
Although
antithyroid drug therapy is still the first-line treatment of Graves' hyperthyroidism in children in many European countries, radioactive iodine treatment in the USA is often used in children aged 10 years and older.
Abbreviations anti-Tg: hyroglobulin antibodies anti-TPO: hyroid peroxidase antibodies ATD:
Antithyroid drug CS: Cowden syndrome FNA: Fine needle aspiration fT3: Free triiodothyronine fT4: Free thyroxine GD: Graves' disease IQ: Intelligence quotient NCCN: National Comprehensive Cancer Network PTEN: Phosphatase and tensin homolog RAI: Radioiodine TRAbs: hyrotropin receptor antibodies TSH: hyrotropin.
During
antithyroid drug therapy, they noticed marker improvement [26].
Beta-blockers often are added as adjunct therapy in the initial phases of
antithyroid drug treatment to control cardiac symptoms (e.g., tachycardia) of hyperthyroidism (Bartalena, 2013).
The substance is historically relevant in the preparation of
antithyroid drug. Sulfhydryl compounds are known to undergo electrochemical oxidation at solid electrodes, but their oxidation occurs at relatively high potentials [1, 2].
Antithyroid drug (ATD) therapy of Graves' hyperthyroidism is in many patients followed by a remission of the autoimmunity of GD with a gradual disappearance of TRAb from the circulation [5].