Antitetanus immunoglobulin is produced from plasma of young volunteers who received a booster dose of the tetanus-diphtheria vaccine.
In consequence, this approach could be used to purify DAT from plasma of revaccinated persons or from commercial immunoglobulins (i.e., the antitetanus immunoglobulin itself or nonspecific IVIG), which contains variable concentrations of DAT (online Technical Appendix, http:// wwwnc.cdc.gov/EID/article/22/7/15-1670-Techapp1.pdf).