The skin secretion of the amphibian Phyllomedusa nordestina: a source of antimicrobial and
antiprotozoal peptides.
Metronidazole (1-B-hydroxyethyl-2-methyl-5-nitromidazole) is a synthetic anti-bacterial and
antiprotozoal agent16.
The various biological activities exhibited by these compounds were reviewed [8-11] and some of them comprise antimicrobial [12-17], antitubercular [18,19], anticancer [20-23], antioxidant [24, 25],
antiprotozoal [26], anthelmintic [27], antimalarial [28], antiulcer [29], analgesic, and anti-inflammatory ones [30-32].
Kaiser et al., "Assessment of
antiprotozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis," Journal of Ethnopharmacology, vol.
Several research studies about antibacterial,
antiprotozoal, anticancer, antifungal, and antiviral activity of garlic can be found as the current literature is concerned [5].
roseus also contains ursolic acid (triterpene) and this compound is known to possess a wide range of more biological, anticancer [17], antimicrobial [18], hypoglycemic [19],
antiprotozoal (against Plasmodium falciparum) [20], antiplatelet aggregation, anti HIV-ADIS, antimycobacterium tuberculosis, anti-inflammatory [18], and antioxidant [21] activities.
The
antiprotozoal activity of the extract was carried out with the microassay technique as previously described [7].
Structurally related
antiprotozoal drugs, namely, nitroimidazole derivatives including metronidazole (MNZ), secnidazole (SNZ), tinidazole (TNZ), ornidazole (ONZ), and metronidazole benzoate (MB), etc., are a class of veterinary drugs and are used widely as antibacterial and antiprotozoan drugs in poultry and swine dysentery [1].
Several studies have documented the biocidal functions of propolis, including antibacterial, antifungal,
antiprotozoal, antiviral, anti-tumor, immune-modulation and anti-inflammatory activities (Mello et al.
Antifungal, antiviral, and
antiprotozoal activities have also been reported previously (Dua et al., 2013).
In vitro evaluation of portuguese propolis and floral sources for
antiprotozoal, antibacterial and antifungal activity.
The cases most frequently involved analgesic and non-steroidal anti-inflammatory drugs (n=373, 25.2%); antiepileptic, antipsychotic, psychoactive, and anxiolytic drugs (n=229, 16.3%); antihistamine, asthma, flu, and cough drugs (n=157, 12.0%); and antibiotic, anti-fungal; and
antiprotozoal drugs (n=74, 5.0%).