There are many other potentially risky anticholinergic drugs beyond these, but this study noted that antihistamines, gastrointestinal antispasmodics,
antimuscarinic bronchodilators, antiarrhythmics, and skeletal muscle relaxants did not significantly elevate the risk of dementia.
New use of inhaled long-acting beta, agonists or long-acting
antimuscarinic antagonists was associated with a 1.5-fold increased cardiovascular risk within 30 days of initiation in patients with chronic obstructive pulmonary disease, irrespective of prior cardiovascular disease status and history of exacerbations, according to a review of more than 280,000 COPD patients in Taiwan.
Scopolamine is an
antimuscarinic agent, which means it has an effect on the central nervous system.
Despite their established clinical efficacy in the medical treatment of OAB, the side effects, tolerability issues, and low persistence rates associated with
antimuscarinic drugs have contributed to the development of alternative, non-muscarinic targets for OAB pharmacotherapy.
Urge incontinence is commonly treated with lifestyle changes, behavior modifications,
antimuscarinic medications, and some other third-line treatments.
Therefore, agents with
antimuscarinic properties, such as oxybutynin, tolterodine, and gabapentin are used to relieve it.
For bronchospasm refractory to standard atropine therapy consider that inhaled or nebulized ipratropium (or another
antimuscarinic medication) can be combined with adjunct beta-agonists such as albuterol, terbutaline, formeterol, or salmeterol.
Scopolamine-induced convulsions in fasted mice after food intake: effects of glucose intake,
antimuscarinic activity and anticonvulsant drugs.
Pharmacological characterization of a new
antimuscarinic agent, solifenacin succinate, in comparison with other
antimuscarinic agents.
Hyoscine, a quaternary derivative of atropine, is an
antimuscarinic agent which acts by inhibiting cholinergic transmission in the parasympathetic ganglia, thus relieving spasm in the smooth muscle of female genital organs, especially the cervicouterine plexus, thus aiding cervical dilatation.