anti-thrombin III

A 58-kD alpha2-glycoprotein with a single polypeptide chain that inactivates serine proteases (thrombin and other coagulation proteins, including factor Xa, IXa, kallikrein and others) by an irreversible heparin-dependent reaction.

Function
AT-III dissolves blood clots that normally form within the circulation; heparin’s anticoagulant activity hinges on activation of AT-III. Decreased AT-III may be a congenital AD condition or acquired, occurring in DIC (due to pulmonary tuberculosis) or in liver disease (due to decreased AT-III production), resulting in an increased risk of coagulation.

Ref range
0.15–0.45 mg/mL, or > 50% of lab’s control value.

Increased in
Acute hepatitis, post-renal transplant, inflammation, menstruation, vitamin K deficiency.

Decreased in
Congenital deficiency, liver transplant, DIC, nephrotic syndrome, cirrhosis, chonic liver disease, carcinoma, mid-menstrual cycle; AT-III is defective in 0.14% to 0.5% of the general population.

Mentioned in

References in periodicals archive

A pro thrombotic state in TB can be attributed to elevated plasma fibrinogen, impaired fibrinolysis, decreased levels of anti-thrombin III and reactive thrombocytosis (7, 8).

Disseminated Tuberculosis Manifesting as Hepatic Abscess and IVC Thrombosis: A Rare Presentation

Further laboratory work-up for autoimmune and coagulation disorders, such as anti-phospholipid syndrome, protein-S, protein-C and anti-thrombin III deficiency was negative.

De novo descending aorta thrombus in a patient with metastatic colorectal cancer: A case report

Thrombophilia screening including protein C, protein S, lupus anticoagulant, anticardiolipin antibody, anti-[beta] glycoprotein-I antibody, and anti-thrombin III were all normal.

Deep vein thrombosis as a rare presentation in a female with anti-neutrophil cytoplasmic antibodies-associated vasculitis

Antinuclear antibodies were negative and protein C, protein S, anti-thrombin III and antiphospholipid antibodies profile which were carried out 4 weeks afterwards were within normal limits, hence ruling out any coagulopathy.

Cerebral venous thrombosis: a rare presentation of paroxysmal nocturnal hemoglobinuria

At one side estrogen is found to be thrombogenic by cohorts of the patients using contraceptive pills or receiving hormonal replacement therapy1,2 which is also supported by the fact that a number of pathways are altered by estrogen that effect the cardiovascular system14,15 and many changes in factors influencing coagulation have been reported including increased circulating levels of factors II, VII, IX and X and decreased anti-thrombin III pathway due to hepatic effects16.

THROMBO-EMBOLIC RISK IN HIGH ESTROGENIC PHASE OF NORMAL MENSTRUAL CYCLE IN HEALTHY WOMEN

Fibrinogen degradation products tend to be raised and concentrations of proteins C, S, and anti-thrombin III reduced (9).

Purpura fulminans secondary to rickettsia in a child: a case report

D-dimer was 5.42 pg [mL.sup.-1] (normal range: 0-0.48 pg [mL.sup.-1]), anti-thrombin III activity was 101% (normal range: 80%-120%), plasma protein C and protein S levels were 84% (normal range: 70%-130%) and 92% (normal range: 60%-130%), respectively, and the plasma factor VIII level was 126% (normal range: 53%-170%).

Is swine-origin influenza a predisposing factor for deep vein thrombosis? / Domuz Gribi Derin Ven Trombozu icin Predispozan bir Faktor mudur?

Anti-thrombin III activity was measured with a chromogenic substrate (cat.

Acquired activated protein C resistance associated with IgG antibodies against [[beta].sub.2]-glycoprotein I and prothrombin as a strong risk factor for venous thromboembolism