amoxapine

[ah-mok´sah-pēn]

a tricyclic antidepressant of the dibenzoxazepine class; administered orally.

amoxapine

A tricyclic antidepressant of the dibenzoxazepine class.

Adverse effects
Tardive dyskinesia, sedation, postural hypotension, cholinergic effects (e.g., dry mouth, blurred vision, constipation, urinary retention, weight gain), neuroleptic malignant syndrome, cardiovascular effects (EKG, slow AV conduction); withdrawal symptoms accompany abrupt withdrawal.

Toxic range
> 500 ng/mL.

T1/2
30 hours as metabolite (8-hydroxyamoxipine).

Method
HPLC.

amoxapine

Neuropharmacology A tricyclic antidepressant Adverse effects Tardive dyskinesia, sedation, postural hypotension, cholinergic effects—eg dry mouth, blurred vision, constipation, urinary retention, weight gain, neuroleptic malignant syndrome, cardiovascular effects—EKG, slow AV conduction; withdrawal symptoms accompany abrupt withdrawal

amoxapine

A tricyclic antidepressant drug similar to IMIPRAMINE. Overdosage may cause acute kidney failure, convulsions and coma. A brand name is Asendis.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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References in periodicals archive

Table 1 Medications that can cause serotonin syndrome Action Medications Increases serotonin Tryptophan formation Increases release of Amphetamines and amphetamine derivatives serotonin Cocaine MDMA Impairs serotonin Cocaine, MDMA, meperidine, reuptake tramadol, pentazocine SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) SNRIs (desvenlafaxine, duloxetine, milnacipran, venlafaxine, levomilnacipran) Dopamine-norepinephrine reuptake inhibitors (bupropion) Serotonin modulators (nefazodone, trazodone, vilazodone, vortioxetine) TCAs (amitriptyline, amoxapine, clomipramine, desipramine, doxepin) St.

Differentiating serotonin syndrome and neuroleptic malignant syndrome: Symptoms can overlap, but accurate diagnosis is critical because treatments are distinct

Pies, MD, because loxapine is converted into amoxapine (an antidepressant), it could benefit patients with psychosis and depression.

Loxapine is indeed underused

The National Pregnancy Registry for Antidepressants (844-405-6185) is studying amitriptyline (Elavil), amoxapine (Asendin), bupropion (Forfivo XL and Wellbutrin), Citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), desvenlafaxine (Prisiq), doxepin (Sinequan), escitalopram (Lexapro), fluvoxamine (Luvox), fluoxetine (Prozac), imipramine (Tofranil), isocarboxazid (Marplan), levomilnacipran (Fetzima), maprotiline (Ludiomil), mirtazapine (Remeron), nefazodone (Serzone), nortriptyline (Pamelor), paroxetine (Paxil), phenelzine (Nardill), protriptyline (Vivactil), selegiline (Emsam), sertraline (Zoloft), tranylcypromine (Parnate), trazodone (Desyrel), trimipramine (Surmontil), venlafaxine (Effexor), and vilazodone (Viibryd).

Pregnancy registries are a valuable resource

Osterberg, "The neuropharmacological actions of amoxapine," Archives Internationales De Pharmacodynamie Et De Therapie, vol.

Enhancing Antidepressant Effect of Poloxamer/Chitosan Thermosensitive Gel Containing Curcumin-Cyclodextrin Inclusion Complex

Did not observe use of the following antidepressants: Amoxapine, Clomipramine, Imipramine, Maprotiline, Protriptyline, Trimipramine, Vilazodone, Vortioxetine, and Nefazodone.

Depression Treatment among Adults with Multiple Sclerosis and Depression in Ambulatory Care Settings in the United States

Various antidepressant drugs have a piperazine nucleus such as amoxapine, befuraline.

Preparation and Spectral Properties of Novel N,S-Substituted Trichloronitrodienes

In this group, reboxetine (2 mg) showed the maximum price variation of 900%, while amoxapine (50 mg) showed the minimum price variation of 17.72%.

Cost analysis of oral antidepressant drugs available in India

Measurement of plasma concentrations: Sample preparation for analysis consisted of adding 300 [micro]L of acetonitrile containing 100 ng/mL amoxapine (100%, Sigma-Aldrich, St Louis, MO, USA), which served as the internal standard, to 100 [micro]L of parrot plasma in a 96-well, 1-mL protein precipitation filter plate (Thermo Scientific, Waltham, MA, USA).

Pharmacokinetics of single oral dose of Pimobendan in Hispaniolan Amazon parrots (Amazona ventralis)