Generally, a good response to treatment with
alfacalcidol or calcitriol (10-400 ng/kg/day) is expected in cases with VDDR1A (4,21).
Most clinicians (84%, n=158) prescribe Cholecalciferol, 19 (10.1%)
Alfacalcidol and 11 (5.9%) prescribe Calcitriol as a vitamin D supplement, while 155 (82.4%) prescribe a maintenance dose.
As expected, most studies compared bisphosphonates with Vitamin D analogs (cholecalciferol,
alfacalcidol, and calcitriol) or placebo treatment.
The patient was placed on active vitamin D (
alfacalcidol) and calcium supplements.
The following search terms were used: ("vitamin D" OR "vitamin D2" OR "vitamin D3" OR cholecalciferol OR ergocalciferol OR alphacalcidol OR
alfacalcidol OR calcitriol OR paricalcitol OR doxerocalciferol OR "25 (OH)D") AND (pre-diabet* OR diabet* OR T2DM OR TIIDM or "Type 2 DM" OR "Type II DM" OR insulin OR Homa* OR OGTT OR "impaired fasting glucose" OR IFG OR "fasting plasma glucose" OR FPG OR hba1c OR "beta cell") AND (random* or RCT).
This patient was initially treated with an intravenous calcium infusion and subsequently started on chronic oral calcium supplementation along with
alfacalcidol to maintain a serum calcium level in the low normal range.
(14) with alendronate sodium and
alfacalcidol. Azuma et al.
For the management of CKD-MBD, 76.9% of the patients were on calcium carbonate and 64.3% on
alfacalcidol with a similar distribution of drug usage across the groups.
Masuda et al., "Clinical trial: Comparison of alendronate and
alfacalcidol in glucocorticoid-associated osteoporosis in patients with ulcerative colitis," Alimentary Pharmacology and Therapeutics, vol.