aldose reductase inhibitor

Any of a family of compounds (e.g., epalrestat, ponalrestat, sorbinil, tolrestat) that block aldose reductase, which catalyses the reduction of glucose to sorbitol; accumulation of polyols through the autosomal recessive pathway is believed to lead to microvascular and neurologic complications of diabetes. Increased intracellular glucose leads to increased sorbitol, which competitively inhibits glomerular and neural synthesis of myo-inositol; the decrease in myo-inositol synthesis depresses phosphoinositide metabolism and reduces Na+K+-ATPase activity. ARIs do not prevent the complications of type-1 diabetes.

aldose reductase inhibitor

Clinical therapeutics Any of a family of compounds–eg, epalrestat, ponalrestat, sorbinil, tolrestat, which block aldose reductase; ↑ intracellular glucose leads to ↑ sorbitol, which competitively inhibits glomerular and neural synthesis of myo-inositol; the ↓ in myo-inositol synthesis depresses phosphoinositide metabolism, and ↓ in Na+K+-ATPase activity; ARIs do not prevent the complications of type 1 DM See Aldose reductase.

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References in periodicals archive

Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications.

Synthesis and Aldose Reductase Inhibitory Effect of Some New Hydrazinecarbothioamides and 4-Thiazolidinones Bearing an Imidazo[2,1-b] Thiazole Moiety/Imidazo[2,1-b]Tiyazol Cekirdegi Tasiyan Bazi Yeni Hidrazinkarbotiyoamitler ve 4-Tiyazolidinonlarin Sentezi ve Aldoz Reduktaz Inhibitor Etkileri

Cavaliere et al., "A meta-analysis of trials on aldose reductase inhibitors in diabetic peripheral neuropathy," Diabetic Medicine, vol.

The effect of angipars on diabetic neuropathy in STZ-induced diabetic male rats: a study on behavioral, electrophysiological, sciatic histological and ultrastructural indices

La Motta et al., "Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening," Journal of Medicinal Chemistry, vol.

Inhibition of ocular aldose reductase by a new benzofuroxane derivative ameliorates rat endotoxic uveitis

"Oral administration of aldose reductase inhibitors works effectively in experimental animals.

Indian origin boffin's discovery may lead to powerful new asthma treatment

Aldose reductase inhibitors can block the polyol pathway and have been used to deliberate the development of diabetic cardiovascular autonomic neuropathy (DCAN).

The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Tsubota, "Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor, ONO-2235," The British Journal of Ophthalmology, vol.

Evaluation of corneal endothelium in children and adolescents with type 1 diabetes mellitus

This aldose reductase inhibitor is in Phase III testing.

Seven medicines to battle diabetes are in the pipeline

Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor. Science 221, 1177-1178.

Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity

Continuous inhibition of excessive polyol pathway flux in peripheral nerves by aldose reductase inhibitor fidarestat leads to improvement of diabetic neuropathy.

Aldose reductase inhibitors from the leaves of Myrciaria dubia (H. B. & K.) McVaugh

LaBarbera, "The isolation and characterization of ^-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis," PLoS One, vol.

Diosgenin, a Novel Aldose Reductase Inhibitor, Attenuates the Galactosemic Cataract in Rats