Ventricular arrhythmic models were developed using
aconitine, barium chloride, and myocardial ischemia-reperfusion methods, Wenxin Granule was administered in progressively higher doses.
One of the most famous poisonings accredited to
aconitine, is that of the Roman Emperor Claudius, who died suddenly in 54 AD.
Aconitine is contained in the roots of aconite, a blue or yellow flower with green leaves related to the buttercup.
aconitine: A highly poisonous alkaloid derived from various aconite species.
In addition, Radix Aconiti lateralis Preparata contains very small amounts of the aconitum alkaloids, such as
aconitine, mesaconitine, and hypaconitine, which are highly toxic but can be hydrolyzed to the more active but less toxic alkaloids, including benzoylaconine, benzoylmesaconine, and benzoylhypaconine that have significant anti-inflammatory and antinociceptive activities (Suzuki et al., 1994).
Additionally, [O.sub.3] exposure at ambient concentrations may not cause overt functional effects, but rather may produce latent or subclinical effects that appear only when the myocardium or specialized conduction system is further stressed, for example, as a result of cellular calcium loading with
aconitine. It is uncertain whether [O.sub.3] exposure elicits such effects.
Arrhythmogenesis was assessed 24 hr later by continuous intravenous infusion of
aconitine, an arrhythmogenic drug, while heart rate and electrocardiogram were monitored.
Rats exposed to wDE developed arrhythmia at lower doses of
aconitine than did controls; the dose was even lower in rats exposed to fDE.