However, Pratico noted that previous work showed
zileuton can also impact amyloid.
Compared with untreated animals, tau mice that had received
zileuton performed significantly better on the tests.
Sustained-release hydrophilic matrix tablets of
zileuton: formulation and in vitro/in vivo studies.
As a first test of the role of LTs in this process, we treated rat AMs with a combination of the 5-LO inhibitor
zileuton (20 [micro]M) and the FLAP inhibitor MK886 (1 [micro]M).
As compounds 8a-b were essentially equipotent with
Zileuton (2) and compound (3) (see results of LT inhibition below), analogs of 8b with substituted phenyl were designed and synthesized.
Effect of
zileuton in radicular pain induced by herniated nucleus pulposus in rats.
Willemsen, "
Zileuton for pruritus in Sjoogren-Larsson syndrome: a randomized doubleblind placebo-controlled crossover trial," Acta Dermato Venereologica, vol.
Taken orally,
zileuton inhibits the 5-LO enzyme, which would otherwise catalyze the formation of leukotrienes from arachidonic acid.
Different treatment modalities like cryotherapy, scarification, topical and systemic steroids, antimalarials, chlorambucil, ciclosporin, dapsone, etretinate, fumaric acid esters, isotretinoin, niacinamide, pentoxifylline, photo(chemo)therapy, potassium iodide,
zileuton (a 5-lipoxygenase inhibitor), vitamin E have been tried with variable responses.
Rodrigues, "Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by
zileuton, A 5-lipoxygenase inhibitor," Drug Metabolism and Disposition, vol.
Among known inhibitors, only the antiasthmatic drug
Zileuton (1, Figure 1) is approved for human use as the racemic mixture [2,18].