The Phase IV, 52-week, single-arm, open-label PROVE-HF trial showed that treatment with Entresto significantly improved levels of an important biomarker shown to be associated with prognosis of clinical outcomes in HFrEF, N-terminal pro-B-type natriuretic peptide (NT-proBNP), which was linked for the first time to significant improvements in left
ventricular remodeling and echocardiographic measures of cardiac structure and function[1],[10],[11].
Studies have showed that, the formation of vulnerable plaque and occurrence of coronary event are closely related to left
ventricular remodeling. Intravascular unltrasound can recognize the property of coronary artery lesion and vascular wall structure of old CHD patients, and judge remolding property of plaque and plaque property so as to predict left
ventricular remodeling.10,11 Early identification of the nature of coronary atherosclerotic plaque and its relationship with left heart remodeling is essential for early intervention in the treatment of coronary heart disease.
It appears to be the major factor influencing the pattern of left
ventricular remodeling, particularly in the concentric type.
Age-related left
ventricular remodeling and associated risk for cardiovascular outcomes: The Multi-Ethnic Study of Atherosclerosis.
Left
ventricular remodeling in heart failure: Current concepts in clinical significance and assessment.
Detrimental
ventricular remodeling in patients with congenital complete heart block and chronic right ventricular apical pacing.
Ma et al16 reported that ivabradine enhance myocardial performance, left ventricular function and
ventricular remodeling and even survival in rodent heart failure, including ventricular fibrillation, myocardial infarction, stable angina, and hypertension-induced cardiomyopathy16.
Suselbeck et al., "Intracoronary delivery of injectable bioabsorbable scaffold (IK-5001) to treat left
ventricular remodeling after ST-elevation myocardial infarction: a first-in-man study," Circulation: Cardiovascular Interventions, vol.
AMI is the leading cause of death worldwide, and those who survive are at higher risk for adverse
ventricular remodeling and heart failure [21].
The echocardiogram (Figure 1; Table 1) documented left ventricular dilation in both systole and diastole, reduced fractional shortening (14%) and ejection fraction (30%), and an increased E-point septal separation (14.7mm), which suggested systolic myocardial failure with eccentric left
ventricular remodeling. Also, the left atrium (LA) dimension was increased, as was the LA/aorta ratio (1.83).