Triple antidepressant combination Study SSRI (escitalopram 10mg) + TCA (amitriptyline Restifo [15] 25mg) + NARI (reboxetine 2mg) TeCA (mianserin 20mg) + TCA (nortriptyline 75mg) + NARI (reboxetine 1mg) SNRI (venlafaxine 150mg) + NaSSA (mirtazapine 7.5mg) + NARI (reboxetine 1mg) MAOI (
tranylcypromine 70mg) + TCA (nortriptyline Thomas et al.
(114) In the rodent, flu-oxetine, imipramine and
tranylcypromine, but not NSRI desipramine, stimulate the expression of p11 in the frontal cortex and hippocampus.
A few irreversible or non-selective MAO inhibitors (e.g., phenelzine,
tranylcypromine) are associated strongly with instances of severe serotonin syndrome, but a large number of opiates, analgesics, tricyclic antidepressants, selective serotonin reuptake inhibitors and antimigraine agents have also been implicated.
For patients with refractory bipolar depression, he said his favorite combination has been lamotrigine and MAO inhibitors, particularly
tranylcypromine.
Buspirone (a [5-HT.sub.1A] receptor agonist used for anxiety) may interact with monoamine oxidase inhibitors (MAOIs), such as isocarboxazid, phenelzine, and
tranylcypromine. Use of buspirone with these drugs can increase blood pressure.
"Don't forget phenelzine and
tranylcypromine, with certain dietary/pharmacologic restrictions," Dr.
In the new study Arthur Zelent and his colleagues at the ICR have shown that the key could be an antidepressant called
tranylcypromine (TCP).
* Monoamine oxidase inhibitors, such as phenelzine (Nardil),
tranylcypromine (Parnate)
rights for Fortaz (ceftazidime), Zinacef (cefuroxime), Lanoxin (digoxin), Parnate (
tranylcypromine sulfate) and Zantac Injection (ranitidine hydrochloride) from GlaxoSmithKline PLC (GSK).
phenelzine, isocarboxazid,
tranylcypromine) potentiate brain amine levels by inhibiting the breakdown of brain amines.
Level 4 involved switching to
tranylcypromine (Parnate) or venlafaxine XR plus mirtazapine.
* Monoamine Oxidase Inhibitors (MAOIs): Examples are phenelzine (Nardil) and
tranylcypromine (Parnate).