The symptoms (itching, photophobia, lacrimation, pain) and signs (conjunctival hyperemia /chemosis, size of giant papillae, limbal infiltrate, shield ulcers/keratitis and
trantas dots were recorded.
Dr Stavros
Trantas, a dermatologist for nearly 30 years and a pioneer of botox treatment in Cyprus, has regular clients who do just that.
The patients were put on cyclosporine 0.1% eyedrops two times a day after stopping their previous medication and then evaluated for the symptoms (Itching, discharge, photophobia and watering) and signs (Conjunctival hyperemia, papillary hypertrophy, Horner
Trantas spots and punctata keratitis) and subsequently graded as described below at baseline, on 2nd week, 4th week, and 12th week.
Clinical features include itching red eye with giant papillae,
Trantas dots, bulbar conjunctival pigmentation, and mucous discharge.
(1.) Ververidis, F.,
Trantas, E., Douglas, C., Vollmer, G., Kretzschmar, G., & Panopoulos, N.
Gonioscopy was first developed in 1898 by Alexios
Trantas, a Greek ophthalmologist who discovered that he could see the ACA with a direct ophthalmoscope while indenting the sclera with his finger.
of Patients (Percentage) Symptoms & Signs Topical Supratarsal Topical 0.1% Steroids triamcinolone Cyclosporine (Difluprednate) / Tacrolimus Group I Group II Group III Severe itching 26 (100%) 26 (100%) 15 (57%) Ropy Discharge 26 (100%) 26 (100%) 13 (50%) Photophobia 26 (100%) 26 (100%) 20 (77%) Large papillae 20 (77%) 25 (97%) 1 (3%) Horner
Trantas dots 26 (100%) 26 (100%) 8 (30%) Active shield ulcer 18 (69%) 25 (96%) 0 (3%) Limbal Pannus 26 (100%) 26 (100%) 10 (30%) Table II.
bulbar hyperemia, conjunctival secretions, papillary reaction,
trantas spots, corneal involvement at presentation, the severity of disease was graded as per the method described by Bonini et al.
Large papillae of different shape and size, usually greater than 1mm in diameter, on the upper tarsal conjunctiva characterize the tarsal form, while
Trantas' dots and infiltrates on the limbus are typical of the limbal form.
Subsequently, most of the ophthalmologist during that period (Arlt, Dasmarres, von Graefe, Axenfeld,
Trantas and Herbert) published about this interesting malady.