The 13C NMR chemical shifts of
thioamide with Pd(II) tris-4-chlorophenyl phosphine complexes are given in the experimental section.
A solution of ethanebis(
thioamide) 0.24 g (2 mmol) and 3,5-di-tert-butyl-2-hydroxybenzaldehyde 0.936 g (4 mmol) in 4 ml of DMF were heated under reflux for 24 h.
Synthesis and properties of hydrazones bearing amide,
thioamide and amidine functions.
[sup.1]H-NMR (300.13 MHz, DMSO-[d.sub.6], [delta] ppm): 4.28 (s, 4H, amine), 9.21 (s, 2H,
thioamide), 8.32 (s, 2H, Ar), 7.41 (d, 2H, Ar), 2.31 (d, 4H, OH).
Tholander et al., "Novel
thioamide derivatives as neutral CB1 receptor antagonists," Bioorganic & Medicinal Chemistry Letters, vol.
Of the samples tested in the first phase, we selected three samples with the lowest value of MIC - N,N-phenyl-1,2,3,4-thiatriazole-5-yl-[beta]-resorcylcarbo-
thioamide (PTR), N-3-(1,2,4-dithia-zole-5-thione)[beta]-resorcylcarbothioamide (DTRTA), N,N-phenyl-1,2,3,4-thiatriazol-5-yl-[beta]-resorcylcarbothioamide (PHARA).
The continuation phase with
thioamide, ofloxacin (cycloserin) was implemented under clinical conditions.
Our unique design elements are highlighted in this poster and include pharmacophore modification, prodrug utilization,
thioamide isosteres, and strategic lipophilicity incorporation.
THIOAMIDE DERIVATIVE MODULATES ANNEXIN V EXPRESSION IN HUMAN LIVER CARCINOMA HEPG2) CELLS 35.