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TERT

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TERT

A gene on chromosome 5p15.33 that encodes telomerase reverse transcriptase, which, with TERC (an internal telomerase RNA template), comprises the telomerase holoenzyme complex.
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References in periodicals archive
Keywords: Human telomerase reverse transcriptase, pontin, reptin, dyskerin, telomerase, cancer
Normal and Tumour Tissue mRNA Expressions of Telomerase Complex Genes in Several Types of Cancer
Cochran, "Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells," Cancer Research, vol.
Proinflammatory Cytokines IL-6 and TNF-[alpha] Increased Telomerase Activity through NF-[kappa]B/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells
Significance of immunological detection of human telomerase reverse transcriptase. Am J Pathol.
Expression of human telomerase reverse transcriptase in vulvar intraepithelial neoplasia and squamous cell carcinoma: an immunohistochemical study with survivin and p53
has granted a non-exclusive license to Procter & Gamble relating to Geron's human telomerase reverse transcriptase (hTERT) technology for cell research applications.
Geron Corp. grants license to P&G
The tie-up will see this "immortalisation" process extended by using Geron's human telomerase reverse transcriptase (hTERT) technology to keep the cells alive for longer and make them a closer match to those living cells inside the body.
US deal brings Xcellsyz new deal for science
[2] Nonstandard abbreviations: CTCs, circulating tumor cells; ALDH, aldehyde dehydrogenase; EpCAM, epithelial cell adhesion molecule; MET, mesenchymal-epithelial transition; NSCLC, non-small cell lung cancer; TERT, telomerase reverse transcriptase.
Nanoplatforms for Circulating Tumor Cell Detection in Lung Cancer
reported that strongly repressed human telomerase reverse transcriptase expression decreased telomerase activity and remarkably shortened telomeres by demethylation following 5-aza-dC treatment.
Association between Long Interspersed Nuclear Element-1 Methylation and Relative Telomere Length in Wilms Tumor
Molecular mechanisms involved in endothelial cell aging: role of telomerase reverse transcriptase. Z Gerontol Geriatr.
The Las Vegas A4M conference
METHODS: We measured LTL, as well as mRNA expression and promoter DNA methylation of the telomerase catalytic enzyme gene [human telomerase reverse transcriptase (bTERT)] in blood samples obtained from 63 steel workers on the first day of a workweek (baseline) and after 3 days of work (postexposure).
Effects of short-term exposure to inhalable particulate matter on telomere length, telomerase expression, and telomerase methylation in steel workers
Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage.
Mitochondria and aging conference on the Canary Islands
Mutations in one of 8 genes involved in telomere biology--DKC1, TINF2, TERC, TERT (telomerase reverse transcriptase), NHP2 [NHP2 ribonucleoprotein homolog (yeast)], NOP10 [NOP10 ribonucleoprotein homolog (yeast)], WRAP53 (WD repeat containing, antisense to TP53; formerly TCAB1), and CTC1 (CTS telomere maintenance complex component 1)--can be identified in approximately 50% of patients with clinical features of classic DC, the remainder being as yet uncharacterized (3, 4).
A young adult with aplastic anemia and gray hair
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