PKC activation with Bryostatin-1 promotes BDNF expression and secretion, and synaptogenesis, and provides protective effects against a variety of neurotoxic factors such as amyloidosis,
tauopathy, apoptosis, neuroinflammation, and oxidants.
The preclinical studies show a tau-targeted PROTAC protein degrader eliminated more than 95% of disease-causing tau protein in the brain of a well-characterized mouse
tauopathy model, following parenteral administration.
Several varied proposed theories of AD etiology are amyloid beta toxicity, [4]
tauopathy, [5] inflammation, [6,7] and oxidative stress.
Anti-tau therapies have shown promise in slowing the progression of tau pathology in animal models of
tauopathy. RG6100 is currently in Phase II clinical evaluation for its potential to slow or stop the progression of AD.
However, whether RBD is correlated with
tauopathy is controversial.
(2013) Synaptic alterations in the rTg 4510 mouse model of
tauopathy. J Comp Neurol 521: 1334-1353.
Chronic traumatic encephalopathy in athletes: progressive
tauopathy after repetitive head injury.
Gerson et al., "Tau oligomers associate with inflammation in the brain and retina of
tauopathy mice and in neurodegenerative diseases," Journal of Alzheimer's Disease, vol.
Hunot et al., "Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of
tauopathy," Brain, vol.
Although role of PPAR[gamma] in A[beta] mediated pathogenesis is exhaustively studied, its role in
tauopathy needs to be explored for potential mechanism for reducing the hyper-phosphorylation in-depth.