TGFB3

A gene on chromosome 14q24 that encodes a member of the transforming growth factor beta (TGFB) family of cytokines. These multifunctional peptides up- and downregulate proliferation, differentiation, adhesion, migration, death and other functions in many cell types. TGFBs transduce their signal by binding to transmembrane growth factor receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins; disruption of the TGFB/SMAD pathway has been implicated in various cancers. TGFB3 is involved in embryogenesis and cell differentiation.

Molecular pathology
TGFB3 mutations cause familial arrhythmogenic right ventricular dysplasia type 1.

Mentioned in

ITGA8

References in periodicals archive

Variants of developmental genes (TGFA, TGFB3, and MSX1) and their associations with orofacial clefts: a case-parent triad analysis.

Interaction Effect of Rsal and BamHI Polymorphisms of TGF[alpha], BMP2 and BMP4 on the Occurrence of Non-Syndromic Cleft Lip and Palate in Iranian Patients

This study compared methylation differences and expression differences of 12 genes, including TGFB3, ACSL1, RYR1, ACOX2, PPARG2, NTN1, RIN2, MAPRE1, ADAMTS2, MYOM1, ZDHHC13, and SH3PXD2B.

Comparative analysis on genome-wide DNA methylation in longissimus dorsi muscle between Small Tailed Han and DorperxSmall Tailed Han crossbred sheep

The following 18 genes were identified from the whole genome expression profiles of spleen in GeneNetwork of female and male mice: Csf1r, FoxP3, Gata4, Ifnb1, Ifng, IL-10, IL-17a, IL-19, IL-20, IL-22, IL-22, IL-24, Nkx2-5, Tbx5, Tgfb1, Tgfb2, Tgfb3, and Tpr.

Sex Differences in Correlation with Gene Expression Levels between Ifi200 Family Genes and Four Sets of Immune Disease-Relevant Genes

TGFBR1 and TGFBR2 pathogenic variants were initially shown to cause LDS, with subsequent pathogenic variants identified in SMAD3, TGFB2, and TGFB3. We report a case of a novel pathogenic variant in TGFBR2 and phenotype consistent with LDS [4] and demonstrate pathogenic effects on the downstream protein structure based on novel molecular modeling techniques.

Novel Pathogenic Variant in TGFBR2 Confirmed by Molecular Modeling Is a Rare Cause of Loeys-Dietz Syndrome

Lidral et al (1997) evaluated the association of four candidate genes TGFA, TGFB2, TGFB3, homeobox 7 (MSX1) variations in a population from Philippines; however, no evidence for association of TGFA with nonsyndromic CL/P was found in non-Caucasian population (35).

Association of transforming growth factor alpha polymorphisms with nonsyndromic cleft lip and palate in Iranian population

EVs also express genes involved in TGF-[beta] signaling (TGFB1, TGFB3, FURIN, and ENG).

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Roles in Tumor Growth, Progression, and Drug Resistance

Similarly, they had longer followup after transplantation, higher expression of CDC20, CXCL6, DIABLO, GABRP, KIAA0101, ME2, MMP7, NFATC4, and TGFB3 mRNA, and lower expression of CCL19 and TRADD mRNA (Table 2).

Molecular profiling of acute and chronic rejections of renal allografts

Exposure of cells generated via this method to SHH at day 5 and to FGF8 at day 9 of terminal differentiation and further culture until day 19 in medium supplemented with AA, brain derived neurotrophic factor (BDNF), GDNF, transforming growth factor beta 3 (TGFB3), and cyclic adenosine 3',5'-monophosphate (cAMP) leads to production of Tubulin, Beta 3 Class III (TUBB3) positive neurons coexpressing TH [9].

Generation of Cholinergic and Dopaminergic Interneurons from Human Pluripotent Stem Cells as a Relevant Tool for In Vitro Modeling of Neurological Disorders Pathology and Therapy