TCF7L1

A gene on chromosome 2p11.2 that encodes a transcription factor of the T-cell factor/lymphoid-enhancer factor family, which are activated by beta catenin, mediate Wnt signalling and are repressed by transforming growth factor-beta signalling. TCF7L1 participates in regulating cell cycle genes, in terminal differentiation of epidermal cells and in cell senescence; it contains a high mobility group (HMG)-box DNA-binding domain.

References in periodicals archive

In fact, the intracellular pathways were differentially regulated, showing the specific activation of HESX1, MEIS1, and TCF7L1 in hPDLSCs; the activation of CDYL, GATA6, SALL1, and SMARCAD1 in hGMSCs; and the activation of GBX2, JARID2, and SKIL in hDPSCs.

Stemness Maintenance Properties in Human Oral Stem Cells after Long-Term Passage

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