squalene epoxidase
Also found in: Wikipedia.(redirected from Squalene monooxygenase)
squa·lene e·pox·i·dase
[MIM*602019] an enzyme that catalyzes the conversion of squalene to squalene 2,3-oxide in the endoplasmic reticulum; a required step in order for cyclization to occur, resulting in the synthesis of the first sterol, lanosterol, in steroidogenesis; uses NADPH.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive
Laden and Porter (2001) have shown that resveratrol reduced cholesterol synthesis by inhibiting squalene monooxygenase in vitro, a rate-limiting enzyme in cholesterol biosynthesis.
Resveratrol inhibits human squalene monooxygenase. Nutr.
Additionally,
squalene monooxygenase is exclusively upregulated (8 folds) only in HKI1532 (tolerant genotype).
Several of the genes that were found by the microarray study to be more highly transcribed in androgen ablation-resistant tumors encoded biosynthetic enzymes involved in the synthesis of cholesterol, including HMG-CoA synthase, squalene synthase, lanosterol synthase, and
squalene monooxygenase, the rate-limiting enzyme in sterol synthesis.
Copyright © 2003-2025 Farlex, Inc
Disclaimer
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.