SOX9 (human ortholog of zebrafish Sox9b) is a conserved transcription factor that acts as the master regulator of cartilage development (Akiyama et al.
They identified two transcription factors,
Sox9 and Foxc1, as key to the differentiation of stem cells into salivary gland tissue.
[U.S.A.], June 15 (ANI): A group of scientists from the Northwestern University has identified a key enhancer of
Sox9 - a gene critical for male sex development.
To date, mutations in the SRY,
SOX9 and DMRT1 genes have been reported in only a few patients with 46,XY ovotesticular DSD (3-5).
Expressions of
Sox9, Sox5, and Sox13 transcription factors in mice testis during postnatal development.
Upregulation of microRNA-524-5p enhances the cisplatin sensitivity of gastric cancer cells by modulating proliferation and metastasis via targeting
SOX9. Oncotarget 2017; 8: 574-582, doi: 10.18632/oncotarget.13479.
Especially, bone morphogenetic protein (BMP)-binding endothelial cell precursor-derived regulator (BMPER), forkhead box protein O1 (FOXO1), ectodysplasin A receptor, ring finger protein 149 (RNF149), cluster of differentiation (CD40), tyrosine-protein phosphatase non-receptor type 1 (PTPN1), SRY (sex determining region Y)-box 9 (
SOX9), MYC proto-oncogene (MYC), and macrophage migration inhibitory factor were categorized as genes related to both MAPK cascade and the regulation of MAPK cascade.
Forward mandibular positioning up-regulates
SOX9 and type II collagen expression in the glenoid fossa.
Runx2 is affected by several upstream regulators such as the Wnt/Notch system,
Sox9, Msx2, and hedgehog signaling as well as by cofactors such as Osx and Atf4 [1-4].
Let-7 also inhibits cell proliferation by regulating transcriptional factors such as STAT3, E2F5, E2F6, CBFB, PLAGL2,
SOX9, GZF1, YAP1, GTF2I, and ARID3A [42, 43].