Mutant
SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis.
Lennon et al., "Amyotrophic lateral sclerosis-associated
SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria," Neuron, vol.
EZH2 Suppresses
SOD1 Transexpression in Lung in TAC-Induced PAH Mice.
ARE is a cis-regulatory element with specific DNA sequences that are present in the upstream regulatory regions of genes encoding a series of detoxifying enzymes such as HO-1 and
SOD1 [4].
Adult B6.Cg-Tg(SOD1-G93A)1Gur/J mice expressing high copy number of mutant human
SOD1 with a Gly93Ala substitution ([SOD1.sup.G93A]) and adult B6SJLTgN(
SOD1)2Gur mice expressing wild-type human
SOD1 were originally obtained from Jackson Laboratories (Bar Harbor, ME, USA).
SOD1 und amyotrophic lateral sclerosis: mutation and oligomerization.
Gene expression patterns related to the apoptosis pathway (pro-apoptotic p53, and Bax), apoptosis protease-activating factor (caspase-9 and caspase-3), anti-apoptotic (Bcl-2) and oxidative stress (Cat, Gpxla and
Sod1) were also examined to elucidate the potential molecular mechanism underlying the induction of oxidative stress and apoptosis by the PFOS and ZnO-NPs.
The yeast strains used in this study were the wild-type strain YPH250 (MATa trp1-[DELTA]1 his3-[DELTA]200 lys2-801 leu2-[DELTA]1 ade2-101 ura3-52) and its isogenic mutants [DELTA]sod1 (as YPH250 but
sod1::URA3), [DELTA]sod1[DELTA]sod2 (as YPH250 but
sod1::kanMX2 sod2[DELTA]::TRP1), [DELTAc]ta1[DELTAc]tt1 (as YPH250 but cta1::TRP1 ctt1::URA3), [DELTA]yap1 (as YPH250 but yap1-[DELTA]1::HIS3), and [DELTA]gsh1 (as YPH250 but gsh1::LEU2).
VEGF-B was not detectable in quiescent astroglia in
SOD1 mice, but its expression became prominent in activated astrocytes thought to maintain survival of motor neurons after injury [31].
There are three main endogenous antioxidant systems: superoxide dismutase 1 (
SOD1), superoxide dismutase 2 (SOD2), and catalase (CAT).