SIRPA

A gene on chromosome 20p13 that encodes a ubiquitous immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment, and may play a key role in intracellular signalling during synaptogenesis and in synaptic function. It downregulates receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors and insulin; it also downregulates phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. It is highly expressed in the brain.

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References in periodicals archive

Georgie is joined at SIRPA by co-directors Greg Smith and Paul Scott, who complement her role as practitioner and researcher with their expertise - Greg as a former director of a plc and Paul who has skills in marketing, IT and social media.

With SIRPA, Georgie is busy updating an existing CD as well as producing an e-book and a newsletter to spread the word about stress illness recovery.

When it's all in the mind

Roy Cameron today spoke on behalf of himself and Sirpa.

"Finally, myself and Sirpa would like to ask people to please light a candle for Sara this Christmas."

New hope in unsolved student slaying riddle

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