TLC590 is a proprietary BioSeizer liposomal formulation of
ropivacaine intended for the relief of postsurgical pain.
Long acting anesthetics drugs such as etidocaine, bupivacaine, tetracaine,
ropivacaine are mainly used for postoperative and intraoperative pain management.
(7) The present study was done to compare the analgesic and sedative effects of these drugs when used epidurally as neuraxial adjuvants with
ropivacaine.
Patients were randomly grouped into group A (RG) where 20 ml of
ropivacaine 0.25% was used and group B (SG) where 20 ml saline was used.
Then, we injected the prepared mixture of 0.75%
ropivacaine (10 ml, Naropin, AstraZeneca, Luton, UK) and saline (10 ml) with epinephrine (1:200,000), and a 19-gauge catheter was inserted 2 cm over the tip of the needle under real-time ultrasound guidance [Figure 1]b and [Figure 1]c.{Figure 1}
The company said PRF-110 is an extended release version of
ropivacaine providing longer relief of post-surgical incision pain.
CHICAGO --
Ropivacaine has a fast onset of action, has longer duration than either lidocaine or bupivacaine, and is the only one of the three that's inherently vasoconstrictive.
Ropivacaine, an amide local anesthetic, structurally related to bupivacaine, is usually preferred over bupivacaine, as it provides adequate postoperative analgesia along with lesser motor blockade which is desirable in pediatric patients and proved to be more suitable for caudal epidural analgesia, especially during day care surgeries.
Various single enantiomeric drugs such as levobupivacaine and
ropivacaine are now being used, with concerns regarding cardiac toxicity of racemic bupivacaine.
In pediatrics little is known about the absolute maximum dosages for epidural infusion of
ropivacaine. Only two studies [2,3] have been performed in pediatrics assessing the save use of
ropivacaine given via continuous epidural infusion for maximum dose of 0.4 mg [kg.sup.-1] [h.sup.-1].
In this paper, we present the data from a randomized clinical trial performed to assess the impact of local anesthetic wound infiltration with
ropivacaine for postoperative pain relief after osteosynthesis of extracapsular hip fracture.