Resiniferatoxin could be administered to patients at doses and for intervals that result in maximum protection and fewest side effects.
Chen, "
Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action," The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, vol.
Euphorbium: modern research on its active principle,
resiniferatoxin, revives an ancient medicine.
Agents to destimulate the nerve endings, such as lidocaine,
resiniferatoxin, and botulinum toxin, have been administered intravesically with some success.
Intravesical therapies with verapamil, lidocaine, and oxybutynin as well as newer agents of
resiniferatoxin and capsaicin are effective but more inconvenient.
Sorrento Therapeutics announced that review of early results from an on-going "declawed cat pain trial" prompted management to assign a high priority to exploring the use of
resiniferatoxin as a local nerve block injection for the control of neuropathic post-amputation residual limb pain in humans.
Petho, "Effect of CP-96,345 a nonpeptide substance P antagonist, capsaicin,
resiniferatoxin and ruthenium red on nociception," Regulatory Peptides, vol.
Bradley Jr., "Memory of pain: the effect of perineural
resiniferatoxin," Anesthesia & Analgesia, vol.
Scintilla's lead program is
resiniferatoxin for the treatment of intractable cancer pain.
Sorrento is also producing
resiniferatoxin, a non-opiate TRPV1 agonist presently in a Phase I/II trial at the NIH to treat terminal cancer patients suffering from intractable pain.