Biochemistry and function of
pteridine synthesis in human and murine macrophages.
In this context they have proved that bioisosteric replacement of
pteridine ring with Trifluoro-6-methylquinoxaline and trifluoro-7-quinoxaline affords a good substrate for the biological activity in the series of the classical antifolate analogs, whereas this was so in a few cases of the series of nonclassical ones.
M can be synthesized through the ring-opening reaction of an epoxide (2-propenoic acid, 2-methyl-, oxiranyl ester) with a
pteridine containing a hydroxyl group (2, 4-diamino-6-hydroxymethylpteridine) and an aluminum triflate as catalyst [62].
And this is not a solo report as it has been stated that changes in metabolic pathways involving
pteridine reductase and trypanothione reductase play a role in attaining resistance in Leishmania.
In monocyte-derived macrophages and dendritic cells, IFN-[gamma] triggers GTP-cyclohydrolase-I, the key enzyme for the biosynthesis of
pteridine derivatives like neopterin and 5,6,7,8-tetrahydrobioptein (BH4) 2-4].
Kendall, "Clinical role of
pteridine therapy in tetrahydrobiopterin deficiency," Journal of Inherited Metabolic Disease, vol.
These results indicate that abnormal
pteridine metabolism contributes to causing endothelial dysfunction and the enhancement of vascular oxidative stress in the insulin-resistant state.
The carotenoid-based and
pteridine pigments found in the pigmented skin of L.
Neopterin (6-D-erythro-hydroxy propyl
pteridine) is a catabolic product of the purine nucleotide guanosine triphosphate.
Leishmania donovani: oral therapy with glycosyl 1,4-dihydropyridine analogue showing apoptosis like phenotypes targeting
pteridine reductase 1 in intracellular amastigotes.
Neopterin, a
pteridine derivative secreted by interferon-gammastimulated macrophages, is used as a biochemical marker for cellular immune response.