Nerve axons in the retina make synapses at the mesencephalon, lateral geniculate nucleus,
pretectum, and hypothalamus.
These perforating arteries are of utmost importance and irrigate the posterior part of the thalamus, medial ventral thalami, the walls of the third ventricle, hypothalamus, and subthalamic-mesencephalic junctions (subthalamus, substantia nigra, red nucleus, oculomotor nucleus, trochlear nucleus, reticular formation of the midbrain,
pretectum, rhomboid fossa, and the posterior part of the internal capsule) [7-17].
Lund, "Extent and duration of recovered pupillary light reflex following retinal ganglion cell axon regeneration through peripheral nerve grafts directed to the
pretectum in adult rats," Experimental Neurology, vol.
Supranuclear control of vertical eye movements is subserved by diffuse cortical projections from the frontal and supplementary eye fields reaching the rostral interstitial nuclei of the medial longitudinal fasciculus (riMLF) and the interstitial nuclei of Cajal (inC) at the level of the midbrain
pretectum (7).
In addition, the rostral superior colliculus projects to the Edinger-Westphal nucleus via the primary, shorter route through the
pretectum and also through a secondary, longer route through the nucleus reticularis tegmenti pontis (pons), cerebellar cortex, and cerebellar nuclei.
* Upward gaze palsy results from compression on the
pretectum and superior colliculi
A direct OKN pathway from the retina to the
pretectum (nucleus of the optic tract) as seen in other animals is either weak or non-existent in humans.
Neurons were also found in the
pretectum, midbrain, and cerebellar nuclei that are, in all probability, correlated primarily with vertical eye movements and gaze (not illustrated).