MALT1

A gene on chromosome 18q21 that encodes a protein which enhances BCL10-induced activation of NF-kappaB and is involved in nuclear export of BCL10. MALT1 binds to TRAF6, inducing TRAF6 oligomerisation and activation of its ubiquitin ligase activity; MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.

Molecular pathology
MALT1 translocation t(11;18)(q21;q21) with BIRC2 occurs in ± 50% of cytogenetically abnormal low-grade MALT lymphomas.

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References in periodicals archive

Card9 works with B cell lymphoma10 (Bcl10) and paracaspase, mucosa-associated lymphoid tissue lymphoma translocation protein1 (Malt1), forming a Card9-Bcl10-Malt1 complex, inducing pro-inflammatory signals via the canonical NF-[kappa]B pathway and stimulating the p38MAPK and c-June N-terminal kinase pathways (3,4).

Therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis

(4) The t(11;18)(q21;q21) chromosomal translocation, resulting in the production of a fusion protein composed of the apoptosis inhibitor API2 on chromosome 11q21 and the paracaspase MALT1 on chromosome 18q21, is the most common structural abnormality identified in the primary pulmonary MZL.

Lymphoproliferative neoplasms of the lung: a review

Identification of paracaspases and metacaspases: two ancient families of caspaselike proteins, one of which plays a key role in MALT lymphoma.

Miltefosine induces metacaspase and PARP genes expression in Leishmania infantum

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