Disadvantage of investigation of
pancreatic juice is the need for upper endoscopy to obtain it.
Under normal conditions, the pH of liver bile is 7.5 to 8.8, and the
pancreatic juice has a pH of 7.1 to 8.2.
reported that high alcohol consumption of ethanol >50 g/day increased the risk of pancreatic stone development and atrophy, indicating that changes of
pancreatic juice character due to high alcohol consumption may in part contribute to stone formation in AIP [31].
Conventional allele-specific PCR revealed the presence of one or more KRAS mutant alleles in 26 (62%) of 42 samples of
pancreatic juice from carcinoma cases.
Another intestinal hormone that stimulates the secretion of
pancreatic juice is called pancreozymin.
We know that people who have a family history of inflammation of the pancreas tend to have a higher risk, so doctors are testing their
pancreatic juice for pre-cancerous cell changes.
This hypothesis is supported by the findings that alcohol (1) reduces pancreatic secretions (as stated earlier); (2) leads to increased viscosity of pancreatic secretions; (3) decreases citrate concentration in
pancreatic juice, a known predisposing factor for crystal formation; and (4) produces proteins thought to increase stone formation, such as pancreatic stone protein (PSP) and glycoprotein-2 (GP-2) (Stevens et al.
Each patient underwent EUS with radial and linear echoendoscopes as well as
pancreatic juice collection for IL-8 concentration.
Their alkalinity helps neutralize the chymo acid that originates in the stomach, and also provides optimal conditions for enzyme action on
pancreatic juices (Morikawa et al.; Olsen et al., 1994).
(1) The other 98 percent produces and secretes
pancreatic juice, vital for the proper metabolism of everything we eat.
Our current study protocol involves the collection of blood, stool, and
pancreatic juice from these individuals and examining them for different potential tumor markers.
When a cytologist finds no malignant cells in a sample of the
pancreatic juice or tissue obtained from a mucinous tumor, the elderly patient who has been advised to undergo a Whipple procedure faces a dilemma and major life decision.