Alarge-scale replication study identifies TNIP1,
PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
H3K9 is methylated by the KMT1 family (SUV39H1, SUV39H2, G9A, GLP, SETDB1, and SETDB2) as well as
PRDM1, PRDM2, and PRDM4.
Blimp1 (B-lymphocyteinduced maturation protein1) tambien conocido como
Prdm1, funciona mediante la formacion de un complejo con Prmt5 (arginine metiltransferase).
A large scale replication study confirmed some of these associations and identified TNIP1
PRDM1 JAZF1 UHRF1BP1 and IL10 as risk loci for SLE (Gateva et al 2009).
Hom et al., "A large-scale replication study identifies TNIP1,
PRDM1, JAZF1, UHRF1BP1 and IL10 as riskloci for systemic lupus erythematosus," Nature Genetics, vol.
Cells with the protective version of both markers expressed
PRDM1 after being exposed to radiation.
The researchers further traced this observation to a gene called
Prdm1 encoding the protein BLIMP-1, increased expression of which leads to differentiation and proliferation of plasma cells in B cell immune response (Figure 2).
Analyses at the protein level using flow cytometry further confirmed that IL-23 induces the expression of Bcl6 rather than of Blimp-1 (encoded by
PRDM1) on [T.sub.FH] cells [21].