References in periodicals archive

The adipokine plasminogen activator inhibitor 1 (PAI1) was also present in high levels.

Adipose Tissue-Secreted Factors Alter Bladder Cancer Cell Migration

Further significant differences were found for uPA and PAI1 between the different pT-stages (R = 0.007; R < 0.001) (Figures 3(a) and 3(b)) and grading (R < 0.001; R = 0.007) (Figures 3(e) and 3(f)).

Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study

These findings indicated that during LPS-induced inflammatory reaction, PAI1 promotes inflammation through the TLR4/MyD88/NF[kappa]B pathway.

Plasminogen activator inhibitor-1 regulates LPS induced inflammation in rat macrophages through autophagy activation

The inhibitor compounds (used as ligands in docking studies) so far identified against PAI1 protein were collected from various databases, namely, Human Metabolome Database (HMDB) [8], DrugBank [9], Pharmacogenomic knowledgebase (PharmaGKB) [10], and PDB.

An in silico approach towards the prediction of druglikeness properties of inhibitors of plasminogen activator inhibitor1

Moderate alcohol consumption can mediate additional cardioprotection by promoting the dissolution of blood clots through its actions on one or more of the components of the fibrinolytic system (i.e., t-PA, u-PA, PAI1, and fibrinogen).

Focus on: the cardiovascular system: what did we learn from the French (Paradox)?

Among the most important genes up-regulated in ECs in this condition (36) are those that denote EC activation, (45) namely, IL-8, MCP1, VCAM1, PAI1, Gro-[alpha], and E-selectin.

Trends in genomic analysis of the cardiovascular system. (Advances in the Science of Pathology)

In addition, REV-ERB[alpha] acts as a transrepressor for a number of genes, including bmal1 [14], apolipoprotein AI (apoAI) [21], apoCIII [22], fibrinogen-[beta] [23], plasminogen activator inhibitor type 1 (pai1) [24], il6 [7], and ccl2 [5], which indicates that the nuclear hormone receptor plays an important role in the regulation of metabolism, the cardiovascular system, and inflammation.

Direct and indirect suppression of interleukin-6 gene expression in murine macrophages by nuclear orphan receptor REV-ERB[alpha]

Regarding pro-inflammatory cytokines, visceral AT is associated with higher production of TNFalpha [106, 115], plasminogen activator inhibitor 1 (PAI1) [116], IL6, and CRP [117], while producing lower amounts of the anti-inflammatory, insulin-sensitizing adipokine adiponectin, which correlates more strongly with subcutaneous fat [118].

Estrogen signaling in metabolic inflammation

We present here a single-step method for genotyping of the 4G/5G polymorphism of the PAI1 gene that uses rapid-cycle PCR and subsequent analysis with resonance energy transfer probes on a thermal cycler with real-time fluorescence monitoring (15).

Rapid, homogeneous genotyping of the 4G/5G polymorphism in the promoter region of the PAI1 gene by fluorescence resonance energy transfer and probe melting curves

Hyperglycemia-induced oxidative stress in endothelial cells has been reported to upregulate plasminogen activator inhibitor 1 (PAI1) preventing fibrinolysis [53], downregulate the platelet inhibitor prostacyclin [54], and increase production of extracellular matrix [55].

Epigenetic changes in endothelial progenitors as a possible cellular basis for glycemic memory in diabetic vascular complications