Abbreviations: WEL, wedelolactone; OH, hydroxyl group; UGT, uridine diphosphate-glucuronosyltransferase; HPLC, high-performance liquid chromatography; SPE, solid-phase extraction; NMR, nuclear magnetic resonance; UPLC, ultraperformance liquid chromatography; Q-TOF MS, quadruple time-of-flight mass spectrometry; HLM, human liver microsome; HIM, human intestine microsome; HKM, human kidney microsome; UDPGA, uridine 5'-diphosphate-glucuronic acid; UV, ultraviolet; COSY, correlation spectroscopy; HSQC, heteronuclear single quantum correlation spectroscopy; HMBC, heteronuclear multibond correlation spectroscopy; ROESY, rotating frame nuclear
Overhauser effect spectroscopy; IDA, information-dependent acquisition; DMSO, dimethyl sulfoxide.
On the one hand H-7' notably gives HMBCcorrelation with the phenyl C-1' quaternary carbon at dC140.7 ppm and NOE (nuclear
Overhauser effect)correlations with the H-2'/H-6' phenyl protons at dH 7.18 ppm (dC 128.6) and with the H-3'/H-5' phenyl protons at dH7.21 ppm (dC 128.7 ppm).
Hart, "Determination of molecular geometry by quantitative application of the nuclear
Overhauser effect," Journal of the American Chemical Society, vol.
Williamson, The Nuclear
Overhauser Effect in Structural and Conformational Analysis, VCH Publisher, New York, NY, USA, 1989.
The position of the methoxy groups was confirmed by the observation of a nuclear
Overhauser effect between methoxy protons and H-2'.
Friebolin tracks the trends and makes sure students learn the basics as well in his chapters on the physical basis of NMR spectroscopy, the chemical shift, indirect spin-spin coupling, spectrum analysis and calculations, double resonance experiments, assignment of signals, relaxation, one- dimensional NMR experiments using complex pulse sequences, 2D NMR spectroscopy, the nuclear
Overhauser effect, Dynamic NMR spectroscopy, shift reagents, macromolecules, and NMR spectroscopy in biology and medicine.
The Conformation of NaAD Bound to NAD-Synthetase Determined by Transferred Nuclear
Overhauser Effect Spectroscopy.
The two dimensional experiments include the TOCSY and the NOESY and distances are obtained from the nuclear
Overhauser effect. A major study involves the collagen monomer telopeptides which are located at each end of the collagen triple helix.
The reader learns of the growing application of NMR (nuclear magnetic resonance) to the study of protein structure, with its 3 pulse schemes, COSY (correlation spectroscopy), TOCSY (total correlation spectroscopy), and NOESY (nuclear
Overhauser effect spectroscopy).
The structures of 2-OH-CB 77 and 4-OH-CB 56 were assigned by [sup.1]H nuclear
Overhauser effect (NOE) nuclear magnetic resonance (NMR) experiments.
Russell Bell, FCIC, widely known for his early studies of the use of the nuclear
Overhauser effect in organic structure elucidation by NMR, is currently involved with the synthesis and NMR spectroscopy of heteroaromatic cyclophanes, focusing on the aromatic heterobases present in RNA and DNA.
Signals from water were suppressed by use of the nuclear
Overhauser effect spectroscopy (NOESY)-presaturation sequence, and a spectral window of 12 019 Hz was accumulated in an acquisition time of 1.36 s.