Orinase
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Orinase
[or´ĭ-nās] trademark for a preparation of
tolbutamide, an oral hypoglycemic
agent.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
Acetohexamide
A first-generation oral sulfonylurea used to reduce glucose in type 2 diabetics whose diabetes can’t be controlled by diet.
Mechanism of action Triggers release of insulin from the pancreas.
Pharmacokinetics Metabolised in liver to an active analogue; excreted via kidneys.
Adverse effects Hypoglycaemic reactions—e.g., coma, nausea, vomiting, dizziness, cholestatic jaundice, agranulocytosis, aplastic and haemolytic anaemia, hypersensitivity, skin reactions including photosensitivity, rash and itching.
Precautions Hypertension, liver and kidney disease, allergiesSegen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
From 1950 to 1995, only one oral drug was available for the treatment of type 2 diabetes: a sulfonylurea (
Orinase, Diabinese).
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