Outcome measures of peripheral
nerve regeneration. Ann.
Crush injuries are being employed in the studies of molecular events that participate in peripheral
nerve regeneration. Withdrawal latency stimulated by nociception and cutaneous stimulation are functionally unadapted in neonatal rats (Miranda et al., 2006).
Effect of platelet rich plasma and fibrin sealant on facial
nerve regeneration in a rat model.
From these results, we infer that Wnt5a gene might affect the peripheral
nerve regeneration via Wnt/c-Jun and PTEN signaling.
Based on the GO and KEGG enrichment results, we found that the neurotransmitter status of neurons are deregulated by the molecular mechanisms linking to the deregulation of the neuroactive neurotransmitter secretion, transmission, and ligand-receptor interaction pathway, while the neuronal regeneration was activated through the molecular mechanisms linking to the positive regulation of cell migration, cell differentiation, cell growth, PI3K signaling, MAPK cascade activity, nerve growth factor receptor activity, and peripheral
nerve regeneration.
[34] demonstrated that motor
nerve regeneration after partial denervation was decreased in long-term diabetic rats, whereas it was enhanced in short-term diabetic animals.
Although the variation and concentration of contained growth factors in PRP influence the degree of tissue regeneration, studies involving suitable preparations for peripheral
nerve regeneration have not been conducted in the past.
Animal experimental studies revealed that topical application of NGF accelerated restoration of corneal sensitivity and promoted cornea epithelial proliferation and
nerve regeneration after laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK) [85-87].
Researchers have confirmed that electrical charges are able to enhance
nerve regeneration by altering protein adsorption during neuron interactions with electroconductive materials [10, 11].
Magnesium supplement promotes sciatic
nerve regeneration and down-regulates inflammatory response.
Peripheral nerve injuries with segmental defects require bridging the gap between the stumps to facilitate
nerve regeneration and a functional recovery.
Advantages for Tissue Engineering and
Nerve Regeneration