Medical

NUDT15

NUDT15

A gene on chromosome 13q14.12 that encodes an enzyme which hydrolyses some nucleoside diphosphate derivatives. Its function in vivo is unknown—it may play a role in DNA synthesis and cell cycle progression by interacting with PCNA. NUDT15 may remove oxidatively damaged guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing its misincorporation into DNA and A:T to C:G transversions.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
In our patients, NUDT15 (i.e., rs116855232) and TPMT (i.e., rs1142345) SNPs were genotyped using a realtime PCR method.
Efficacy and Safety of Immunosuppressive Therapy for PBC-AIH Overlap Syndrome Accompanied by Decompensated Cirrhosis: A Real-World Study
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