Sieling et al., "
NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy," Nature Medicine, vol.
Nucleotide-binding oligomerization domain containing 2 (
NOD2), a member of the NOD-like receptor family, has been found to be one of the critical components
Fish oil enhances intestinal integrity and inhibits TLR4 and
NOD2 signaling pathways in weaned pigs after LPS challenge.
Maternal TLR4 and
NOD2 gene variants, pro-inflammatory phenotype and susceptibility to early-onset preeclampsia and HELLP syndrome.
La estimulacion de
NOD2 con MDP (muramyl dipeptide) induce la formacion de autofagosomas y promueve la presentacion antigenica sobre moleculas del MHC clase II en celulas dendriticas humanas (21).
While the loss of
NOD2 increases the risk of developing Crohn's disease, increased activity of this gene is also thought to exacerbate symptoms.
This encodes for a product (
NOD2 or CARD15), the CD variant of which is associated with increased intestinal permeability in both CD patients and their unaffected relatives.