NLRC5

A gene on chromosome 16q13 that encodes a protein which is a putative regulator of NF-kappaB and type-I and -II interferon signalling pathways; it plays a role in homeostatic control of innate immunity and in antiviral defence.

References in periodicals archive

Ma, "Dexmedetomidine (DEX) protects against hepatic ischemia/reperfusion (I/R) injury by suppressing inflammation and oxidative stress in NLRC5 deficient mice," Biochemical and Biophysical Research Communications, vol.

Effects of Dexmedetomidine Postconditioning on Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Role of the PI3K/Akt-Dependent Signaling Pathway

The binding of these factors to the SXY module allows the further binding of the coactivator CIITA and the NOD-like receptor family CARD domain containing 5 (NLRC5) factors [25, 41, 42].

Biswas et al., "NLR family member NLRC5 is a transcriptional regulator of MHC class I genes," Proceedings of the National Academy of Sciences of the United States of America, vol.

Kufer, "NLRC5 controls basal MHC class I gene expression in an MHC enhanceosome-dependent manner," The Journal of Immunology, vol.

Transcriptional and posttranscriptional regulations of the HLA-G gene

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