NEK2

A gene on chromosome 1q32.2-q41 that encodes a NEK serine/threonine protein kinase involved controlling centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. It phosphorylates CDC20, CROCC, CEP250, HMGA2, MAD2L1, NDC80, NECAB3, NEK11, NINL, NPM1, PPP1CC and SGOL1; it is essential for localisation of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome.

References in periodicals archive

Furthermore, SCEC tissues were found to possess interactive gene networks with FOXM1, TMPO, KIF11, NEK2, and CENPF as common skeleton centered on NUF2 (Supplementary information Figure S4).

Integrated Genome-Wide Analysis of Gene Expression and DNA Copy Number Variations Highlights Stem Cell-Related Pathways in Small Cell Esophageal Carcinoma

For instance, the kinases RSK3, MSK1-2, PLK1-3, NEK2 and MEKK1 have larger gatekeepers (e.g.

E-Pharmacophore Mapping Combined with Virtual Screening and Molecular Docking to Identify Potent and Selective Inhibitors of P90 Ribosomal S6 Kinase (RSK)/E-Farmakofor Haritalanmasi, Sanal Tarama ve Molekuler Kenetlenmenin Birlestirilmesi ile Etkili ve Secici P90 Ribosomal S6 Kinaz (RSK) Inhibitorlerinin Belirlenmesi

Detection of IGF2BP3, HOXB7, and NEK2 mRNA expression in brush cytology specimens as a new diagnostic tool in patients with biliary strictures.

Evaluation of Intraductal Ultrasonography, Endoscopic Brush Cytology and K-ras, P53 Gene Mutation in the Early Diagnosis of Malignant Bile Duct Stricture

To improve the assay, a numerical score called the molecular grade index (MGI) was created by selecting 5 cell-cycle-related genes (BUB1B, CENPA, NEK2, RACGAP1, and RRM2) to be used concurrently with the H/I index to improve risk stratification.

Theranostic and Molecular Classification of Breast Cancer

In the N-terminal region the amino acidic sequence K-E-N, known as KEN motif, is also present, which serves as targeting signal for Cdh1-APC required also for the degradation of other mitotic proteins such as Nek2 and B99 [22].

A new aurora in anaplastic thyroid cancer therapy

Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.

Differential expression of kinase genes in primary hyperparathyroidism: adenoma versus normal and hyperplastic parathyroid tissue