Sirt1 promotes
N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on
N-Myc protein stability.
The
N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications.
N-myc downstream-regulated gene-1 (NDRG1) is a hypoxia-inducible and differentiation-related protein and candidate biomarker in pancreatic cancer.
Among candidate genes,
N-myc downstream-regulated gene-1 (NDRG1) was validated by real-time-PCR and Western blot.
Further,
N-Myc overexpression mechanistically results in the hyperproliferation of myeloid cells by decreasing transforming growth factor [beta] signaling and increasing c-Jun-NH2-kinase signaling to cause AML [14].
c-Myc belongs to a family of related genes,
N-Myc and L-Myc.
During treatment, the family were dealt another blow - Cannon had a gene called
N-myc amplified, which means sufferers are far more likely to relapse.
Berberine attenuated cancer sternness markers CD133, [beta]-catenin,
n-myc, sox2, notch2 and nestin.
Hereditary neuroblastoma predisposition gene is in chromosome 16p12-13, Amplification of the
N-MYC Oncogene seen in roughly 20% and Deletion of the short arm of chromosome 1.
Reduced expression of
N-Myc downstream-regulated gene 2 in human thyroid cancer.