ma·late de·hy·dro·gen·ase (MD),

an enzyme that, using either NAD⁺ or NADP⁺, catalyzes the dehydrogenation of malate to oxaloacetate or its decarboxylation to pyruvate and CO₂. At least six malate dehydrogenases are known, distinguished by their products, use of NAD⁺ or NADP⁺, and specificity of substrate (one acts on d-malate, the rest act on l-malate); one of these proteins is an enzyme in the tricarboxylic acid cycle.

Synonym(s): malic acid dehydrogenase, malic dehydrogenase, malic enzyme, pyruvic-malic carboxylase

Farlex Partner Medical Dictionary © Farlex 2012

malate dehydrogenase

An oxidoreductase (EC 1.1.1.37) in mitochondria and the cytosol that catalyses the reversible NAD+/NADH reaction in the presence of S-malate, yielding oxaloacetate, a step in the citric acid cycle. Malate dehydrogenase is increased in myocardial infarction, hepatocellular necrosis, megaloblastic anaemia, and cancer.

mal·ate de·hy·dro·gen·ase

(mal'āt dē-hī'drō-jĕ-nās)

Any enzyme that catalyzes the dehydrogenation of malate to oxaloacetate. At least six are known; one is an enzyme in the tricarboxylic acid cycle.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

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References in periodicals archive

The gels were stained for esterase (EST) as per the procedure of Glaszmann (1987), acid phosphatase (ACP) Vallejos (1983), alcohol dehydrogenase (ADH) and malate dehydrogenase (MDH) Shaw and Prasad (1970).

EVALUATING GENETIC PURITY OF QUALITY PROTEIN MAIZE (QPM) INBREDS AND HYBRIDS BY BIOCHEMICAL AND SSR MARKERS

Malate dehydrogenase (MDH) is used as a symbolic enzyme of the mitochondrial matrix [14].

Studies on meat color, myoglobin content, enzyme activities, and genes associated with oxidative potential of pigs slaughtered at different growth stages

Malate dehydrogenase was assayed by the method of Mehler et al.

EFFICACY OF COROSOLIC ACID ON MITOCHONDRIAL ENZYMES AND DNA DAMAGE AGAINST CCL4-INDUCED HEPATOTOXIC RATS

Malate dehydrogenase, pyruvate kinase, and glucose-6-phosphate dehydrogenase activities were not affected significantly by dietary CBH levels.

Growth, body composition, and ammonia tolerance of juvenile white shrimp Litopenaeus vannamei fed diets containing different carbohydrate levels at low salinity

MDH: Malate dehydrogenase. LDH: Lactate dehydrogenase)

A study of HB A1C, alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphtase (ALP) levels in acute and chronic liver diseases

Malate dehydrogenase (MDH), a key enzyme in the tricarboxylic acid cycle (TCA), plays important metabolic roles in aerobic energy producing pathways and in malate shuttle (Figure 1) [5].

Enzymatic activity analysis and catalytic essential residues identification of brucella abortus malate dehydrogenase

1.9), Glycerol-3-phosphate dehydrogenase (G3PDH, EC 1.1.1.8), Isocitrate dehydrogenase (IDH, EC 1.1.1.42), L-lactate dehydrogenase (LDH, EC 1.1.1.27), Malate dehydrogenase (MDH, EC 1.1.

Genetic variability in Oligosarcus paranensis (Teleostei: Characiformes) from the Sao Francisco river, Ivai river basin--Parana State, Brazil/Variabilidade Genetica em Oligosarcus paranensis do rio Sao Francisco, Bacia do rio Ivai--Estado do Parana, Brasil

Of the enzyme systems initially assayed, alcohol dehydrogenase (ADH); lactate dehydrogenase (LDH); malate dehydrogenase (MDH); phosphohexose isomerase (PHI/PGI); and 6-phosphogluconate dehydrogenase (6-PGD) resolved consistently.

Phylogenetic analysis of four estrildid finch spp. and an interspecific hybrid

The tested enzymes were aconitase (ACO), acid phosphatase (ACP), alcohol dehydrogenase (ADH), adenylate kinase (AK), arginine aminopeptidase (AMP), diaphorase (DIA), endopetidase (EP), esterase (EST), fructose-1,6-diphosphatase (FDP), glutamate dehydrogenase (GDH), glutamate oxaloacetate transaminase (GOT), hexokinase (HK), isocitrate dehydrogenase (ICD), leucine aminopeptidase (LAP), malate dehydrogenase (MDH), malic enzyme (ME), peptidase with leucyl-alanine (PEP-LA), 6-phosphogluconate dehydrogenase (PGD), phosphoglucoisomerase (GPI), and shikimate dehydrogenase (SKDH) (Siciliano and Shaw, 1976; Vallejos, 1983; Van Geyt and Smed, 1984; Acquaah, 1992).

An Isozyme Marker for Resistance to Root-Knot Nematode in Sugarbeet

1.1.1.42), and sMDH-[A2.sup.*] (malate dehydrogenase, E.C.

Temporal variation in mitochondrial DNA haplotype frequencies in a brown trout (Salmo trutta L.) population that shows stability in nuclear allele frequencies

We scored nucleoside phosphorylase (Nsp), adenosine deaminase (Ada), and 6-phosphogluconate dehydrogenase (6-Pgd) on tris malate (pH 7.4); phosphoglucomutase (Pgm-1&2), tripeptide aminopeptidase (Pep-A&B), and malic enzyme (Mod) on tris citrate (pH 8.0); and lactate dehydrogenase (Ldh-1&2), glucose-6-phosphate isomerase (Gpi), and malate dehydrogenase (Mdh-1&2) on amine citrate (pH 6.1).

Genetic structure among subpopulations of the eastern wild turkey (Meleagris gallopavo silvestris)

Bands were revealed for the enzyme systems esterase (EST), according to Scandalios (1969), alcohol dehydrogenase (ADH), phosphoglucose isomerase (PGI), malate dehydrogenase (MDH) and malic enzyme (ME), described by Alfenas (1991), and alpha amylase ([alpha] - AMY), according to Alfenas (1998).

Enzyme expression in indica and japonica rice cultivars under saline stress/Expressao de enzimas em cultivares de arroz indica e japonica sob estresse salino